Publications sélectionnées de la plateforme de protéomique IRIC (depuis 2016):
Homsi C, Rajan RE, Minati R, St-Hilaire E, Bonneil E, Dufresne SF, Wurtele H, Verreault A, Thibault P A rapid and efficient method for the extraction of histone proteins
J. Proteome Res., 22, 2765 (2023)
Shi Ming Li A., Homsi C., Bonneil É., Thibault P., Verreault A., Vedadi M. Histone H4K20 monomethylation enables recombinant nucleosome methylation by PRMT1 in vitro
Biochim. Biophys. Acta Gene Regul. Mech., 1866, 194922 (2023)
Gress V, Roussy M, Boulianne L, Bilodeau M, Cardin S, El-Hachem N, Lisi V, Khakipoor B, Rouette A, Farah A, Théret L, Aubert L, Fatima F, Audemard É, Thibault P, Bonneil É, Chagraoui J, Laramée L, Gendron P, Jouan L, Jammali S, Paré B, Simpson SM, Tran TH, Duval M, Teira P, Bittencourt H, Santiago R, Barabé F, Sauvageau G, Smith MA, Hébert J, Roux PP, Gruber TA, Lavallée VP, Wilhelm BT, Cellot S. CBFA2T3::GLIS2 pediatric acute megakaryoblastic leukemia is sensitive to BCL-XL inhibition by navitoclax and DT2216
Blood Adv . 2024 Jan 9;8(1):112-129
Sernoskie SC, Bonneil É, Thibault P, Jee A, Uetrecht Involvement of Extracellular Vesicles in the Proinflammatory Response to Clozapine: Implications for Clozapine-Induced Agranulocytosis
J Pharmacol Exp Ther. 388, 827-845 (2024)
Chalkiadaki K, Hooshmandi M, Lach G, Statoulla E, Simbriger K, Amorim IS, Kouloulia S, Zafeiri M, Pothos P, Bonneil É, Gantois I, Popic J, Kim SH, Wong C, Cao R, Komiyama NH, Atlasi Y, Jafarnejad SM, Khoutorsky A, Gkogkas CG Mnk1/2 kinases regulate memory and autism-related behaviours via Syngap1
Brain. 2023 May 2;146(5):2175-2190
Kho I, Demina EP, Pan X, Londono I, Cairo CW, Sturiale L, Palmigiano A, Messina A, Garozzo D, Ung RV, Mac-Way F, Bonneil É, Thibault P, Lemaire M, Morales CR, Pshezhetsky AV. Severe kidney dysfunction in sialidosis mice reveals an essential role for neuraminidase 1 in reabsorption
JCI Insight, 8, e166470 (2023)
Beillevaire D, Migneault F, Turgeon J, Gingras D, Rimbaud AK, Marcoux G, Spino C, Thibodeau N, Bonneil E, Thibault P, Boilard É, Dieudé M, Hébert MJ. Autolysosomes and caspase-3 control the biogenesis and release of immunogenic apoptotic exosomes
Cell Death Dis. 13(2):145 (2022)
Safa-Tahar-Henni S, Páez Martinez K, Gress V, Esparza N, Roques É, Bonnet-Magnaval F, Bilodeau M, Gagné V, Bresson E, Cardin S, El-Hachem N, Iasenza I, Alzial G, Boivin I, Nakamichi N, Soufflet AC, Mirela Pascariu C, Duchaine J, Mathien S, Bonneil É, Eppert K, Marinier A, Sauvageau G, Deblois G, Thibault P, Hébert J, Eaves CJ, Cellot S, Barabé F, Wilhelm BT Comparative small molecule screening of primary human acute leukemias, engineered human leukemia and leukemia cell lines
Leukemia, 39, 29-41 (2025)
Moison C, Gracias D, Schmitt J, Girard S, Spinella JF, Fortier S, Boivin I, Mendoza-Sanchez R, Thavonekham B, MacRae T, Mayotte N, Bonneil E, Wittman M, Carmichael J, Ruel R, Thibault P, Hébert J, Marinier A, Sauvageau G. SF3B1 mutations provide genetic vulnerability to copper ionophores in human acute myeloid leukemia
Sci Adv. 10, eadl4018 (2024)
Vojnits K, Feng Z, Johnson P, Pfammatter S, Thibault P, Bhatia M Targeting of human cancer stem cells predicts efficacy and toxicity of FDA-approved oncology drugs
Cancer lett, 599, 217108 (2024)
Chagraoui J, Girard S, Spinella JF, Simon L, Bonneil E, Mayotte N, MacRae T, Coulombe-Huntington J, Bertomeu T, Moison C, Tomellini E, Thibault P, Tyers M, Marinier A, Sauvageau G UM171 preserves epigenetic marks that are reduced in ex vivo culture of human HSCs via potentiation of the CLR3-KBTBD4 complex
Cell Stem Cell, 28, 48-62e6 (2021)
Baccelli I, Gareau Y, Lehnertz B, Gingras S, Spinella JF, Corneau S, Mayotte N, Girard S, Frechette M, Blouin-Chagnon V, Leveillé K, Boivin I, MacRae T, Krosl J, Thiollier C, Lavallée VP, Kanshin E, Bertomeu T, Coulombe-Huntington J, St-Denis C, Bordeleau ME, Boucher G, Roux PP, Lemieux S, Tyers M, Thibault P, Hébert J, Marinier A, Sauvageau G. Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia
Cancer Cell, 36, 84-99.e8 (2019)
Serwe, G., Kachaner, D., Gagnon, J., Plutoni, C., Lajoie, D., Durame, E., Sahmi, M., Garrido, D., Lefrancois, M., Arseneault, G., Saba-El-Leil, M. K., Meloche, S., Emery, G., and Therrien, M. CNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL signalling
Nat Commun 14, 3560
Houles T, Lavoie G, Nourreddine S, Cheung W, Vaillancourt-Jean É, Guérin CM, Bouttier M, Grondin B, Lin S, Saba-El-Leil MK, Angers S, Meloche S, Roux PP CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma
Nat Commun. 2022 Oct 29;13(1):6457
Wang LT, Proulx MÈ, Kim AD, Lelarge V, McCaffrey L. A A proximity proteomics screen in three-dimensional spheroid cultures identifies novel regulators of lumen formation
Sci Rep. 2021 Nov 23;11(1):22807
Aubert, L., Nandagopal, N., Steinhart, Z., Lavoie, G., Nourreddine, S., Berman, J., Saba-El-Leil, M. K., Papadopoli, D., Lin, S., Hart, T., Macleod, G., Topisirovic, I., Gaboury, L., Fahrni, C. J., Schramek, D., Meloche, S., Angers, S., and Roux, P. P. Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer
Nat Commun 11, 3701
Shestakova, E. A., Boutin, M., Bourassa, S., Bonneil, E., and Bijl, J. J. Identification of proteins associated with transcription factors HOXA9 and E2A-PBX1 by tandem affinity purification
Mol Biol (Mosk) 51, 490-501
Li J, Wang X, Jordana L, Bonneil É, Ginestet V, Ahmed M, Bourouh M, Pascariu CM, Schmeing, TM, Thibault P, Archambault V Mechanisms of PP2A-Ankle2 dependent nuclear reassembly after mitosis
Elife 2025 Feb 18:13:RP104233
Park SLL, Ramírez-Jarquín UN, Shahani N, Rivera O, Sharma M, Joshi PS, Hansalia A, Dagar S, McManus FP, Thibault P, Subramaniam S. SUMO modifies GβL and mediates mTOR signaling
J Biol Chem. 300(4), 105778 (2024)
Emond-Fraser V, Larouche M, Kubiniok P, Bonneil É, Li J, Bourouh M, Frizzi L, Thibault P, Archambault V. Identification of PP2A-B55 targets uncovers regulation of emerin during nuclear envelope reassembly in Drosophila
Open Biol, 13, 230104 (2023)
Li C, Boutet A, Pascariu M, Nelson T, Courcelles M, Wu Z, Comtois-Marotte S, Emery G, Thibault P SUMO Proteomics Analyses Identify Protein Inhibitor of Activated STAT-Mediated Regulatory Networks Involved in Cell Cycle and Cell Proliferation
J. Proteome Res., 22, 812 (2023)
Javary, J., Goupil, E., Soulez, M., Kanshin, E., Bouchard, A., Seternes, O. M., Thibault, P., Labbe, J. C., and Meloche, S. Phosphoproteomic analysis identifies supervillin as an ERK3 substrate regulating cytokinesis and cell ploidy
J Cell Physiol, 239(3):e30938
Li C., Nelson T., Vertegaal AOC, Thibault P Proteomic strategies for characterizing ubiquitin-like modifications
Nature Reviews Methods Primers, 1, 53 (2021)
Li. C. McManus, F.P., Plutoni, C., Pascariu, M.P., Nelson, T., Alberici Delvin L.E., Emery, G., Thibault, P Quantitative SUMO proteomics identifies PIAS1 substrates involved in cell migration and motility
Nature Commun., 11, 834 (2020)
Chen Y, Jin E, Abdouh M, Bonneil É, Jimenez Cruz DA, Tsering T, Zhou Q, Fuentes-Rodriguez A, Bartolomucci A, Goyeneche A, Landreville S, Burnier MN, Burnier JV Co-isolation of human donor eye cells and development of oncogene-mutated melanocytes to study uveal melanoma
BMC Biol. 2025 Jan 21;23(1):16
Joharinia N, Bonneil É, Grandvaux N, Thibault P, Lippé R Comprehensive proteomic analysis of HCoV-OC43 virions and virus-modulated extracellular vesicles
J Virol. 2024 Jul 23;98(7):e0085024
Wu Z, Bonneil É, Belford M, Boeser C, Dunyach JJ, Thibault P Targeted Mass Spectrometry Analyses of Somatic Mutations in Colorectal Cancer Specimens Using Differential Ion Mobility
Proteome Res., 23, 644-652 (2024)
Pfammatter, S., Wu, Z., Bonneil, E., Bailey, D. J., Prasad, S., Belford, M., Rochon, J., Picard, P., Lacoursiere, J., Dunyach, J. J., and Thibault, P. Integration of Segmented Ion Fractionation and Differential Ion Mobility on a Q-Exactive Hybrid Quadrupole Orbitrap Mass Spectrometer
Anal Chem 93, 9817-9825
Pfammatter, S., Bonneil, E., McManus, F. P., and Thibault, P. Accurate Quantitative Proteomic Analyses Using Metabolic Labeling and High Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS)
J Proteome Res 18, 2129-2138
Comtois-Marotte S, Bonneil É, Li C, Smith MJ, Thibault P Epitope and Paratope Mapping of a SUMO-Remnant Antibody Using Cross-Linking Mass Spectrometry and Molecular Docking
J. Proteome Res., (2025)
Noronha N, Durette C, Cahuzac M, E Silva B, Courtois J, Humeau J, Sauvat A, Hardy MP, Vincent K, Laverdure JP, Lanoix J, Baron F, Thibault P, Perreault C, Ehx G Autophagy degrades immunogenic endogenous retroelements induced by 5-azacytidine in acute myeloid leukemia
Leukemia, 38(5), 1019-1031 (2024)
Kina E, Laverdure JP, Durette C, Lanoix J, Courcelles M, Zhao Q, Apavaloaei A, Larouche JD, Hardy MP, Vincent K, Gendron P, Hesnard L, Thériault C, Ruiz Cuevas MV, Ehx G, Thibault P, Perreault C. Breast cancer immunopeptidomes contain numerous shared tumor antigens
J Clin Invest. 2024 Jan 2;134(1):e166740
Larouche JD, Laumont CM, Trofimov A, Vincent K, Hesnard L, Brochu S, Côté C, Humeau JF, Bonneil É, Lanoix J, Durette C, Gendron P, Laverdure JP, Richie ER, Lemieux S, Thibault P, Perreault C Transposable elements regulate thymus development and function
Elife. 12:RP91037 (2024)
Cleyle J, Hardy MP, Minati R, Courcelles M, Durette C, Lanoix J, Laverdure JP, Vincent K, Perreault C, Thibault P Immunopeptidomic analyses of colorectal cancers with and without microsatellite instability
Mol. Cell. Proteomics, 21(5):100228 (2022)
Apavaloaei A, Hesnard L, Hardy MP, Benabdallah B, Ehx G, Thériault C, Laverdure JP, Durette C, Lanoix J, Courcelles M, Noronha N, Chauhan KD, Lemieux S, Beauséjour C, Bhatia M, Thibault P, Perreault C Induced pluripotent stem cells display a distinct set of MHC I-associated peptides shared by human cancers
Cell Reports, 40(7):111241 (2022)